Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The primary objective of this study is to assess the activity of subcutaneous (SC) amifostine on the incidence and severity of acute radiochemotherapy-induced esophagitis in patients with unresectable Stage IIIA or IIIB non-small cell lung cancer (NSCLC) receiving combined modality therapy.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Amifostine | Drug |
| Measure | Description | Time Frame |
|---|---|---|
| - Acute radiochemotherapy-induced esophagitis will be assessed from the time of randomization through up to 3 months after completion of radiochemotherapy treatment. |
| Measure | Description | Time Frame |
|---|---|---|
| - Acute radiochemotherapy-induced pneumonitis will be assessed until 6 months after the last dose of XRT. |
Not provided
You may be eligible for this study if you are 18 years of age or older and:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Luz Hammershaimb, M.D. | MedImmune LLC | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cedars Sanai | Los Angeles | California | 90048 | United States | ||
| Radiation Oncology Center |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Sacramento |
| California |
| 95816 |
| United States |
| The Center for Cancer Care | Torrington | Connecticut | 06790 | United States |
| Florida Wellcare Alliance | Inverness | Florida | 34452 | United States |
| Florida Community Cancer Center | New Port Richey | Florida | 34652 | United States |
| Ormand Memorial Cancer Center | Ormand Beach | Florida | 32174 | United States |
| Sarasota Memorial Hospital | Sarasota | Florida | 34239 | United States |
| University Community Hospital-Center for Cancer Care | Tampa | Florida | 33613 | United States |
| University of Kentucky | Lexington | Kentucky | 40536-0293 | United States |
| St. Agnes Health Care | Baltimore | Maryland | 21229 | United States |
| Center for Cancer & Blood Disorders | Bethesda | Maryland | 20817 | United States |
| Chesapeake Oncology-Hematology Associates | Glen Burnie | Maryland | 21061 | United States |
| St. John's Medical Research | Springfield | Missouri | 65807 | United States |
| Cooper University Hospital | Camden | New Jersey | 08103 | United States |
| Long Island Jewish Medical Center | New Hyde Park | New York | 11040 | United States |
| Beth Israel Hospital | New York | New York | 10003 | United States |
| Upstate NY Cancer R&E Foundation | Rochester | New York | 14623 | United States |
| New Hanover Radiation | Wilmington | North Carolina | 28401 | United States |
| Cancer Center of Upper Delaware Valley | Milford | Pennsylvania | 18337 | United States |
| Montgomery Cancer Center | Norristown | Pennsylvania | 19401 | United States |
| Charleston Cancer Center | Charleston | South Carolina | 29406 | United States |
| The Center for Radiation Oncology | Danville | Virginia | 24541 | United States |
| Providence Everett Medical Center | Everett | Washington | 98201 | United States |
| Valley Medical Center | Renton | Washington | 98055 | United States |
| ID | Term |
|---|---|
| D004941 | Esophagitis |
| D011014 | Pneumonia |
| D002289 | Carcinoma, Non-Small-Cell Lung |
| ID | Term |
|---|---|
| D004935 | Esophageal Diseases |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
| D005759 | Gastroenteritis |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D002283 | Carcinoma, Bronchogenic |
| D001984 | Bronchial Neoplasms |
| D008175 | Lung Neoplasms |
| D012142 | Respiratory Tract Neoplasms |
| D013899 | Thoracic Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
Not provided
Not provided
| ID | Term |
|---|---|
| D004999 | Amifostine |
| ID | Term |
|---|---|
| D063086 | Organothiophosphates |
| D010755 | Organophosphates |
| D009943 | Organophosphorus Compounds |
| D009930 | Organic Chemicals |
| D009946 | Organothiophosphorus Compounds |
| D013457 | Sulfur Compounds |
Not provided
Not provided