| ID | Type | Description | Link |
|---|---|---|---|
| U10MH066762 | U.S. NIH Grant/Contract | View source | |
| U10MH066775 | U.S. NIH Grant/Contract | View source | |
| U10MH066778 | U.S. NIH Grant/Contract | View source | |
| U10MH066769 | U.S. NIH Grant/Contract | View source | |
| U10MH066750 | U.S. NIH Grant/Contract | View source | |
| DDTR B4-ARD |
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| Name | Class |
|---|---|
| National Institute of Mental Health (NIMH) | NIH |
The purpose of this study is to compare the effects of three types of treatments for depressed teenagers who have attempted suicide.
Suicide is the third leading cause of death in adolescents and is a major public health problem. Depression is the most common diagnosis for adolescent suicide attempts. Little is known about what treatment is best for these adolescents since they are usually excluded from participation in research studies.
Participants in this study will be randomly assigned to receive carefully monitored antidepressant medication with routine support and management, cognitive behavioral therapy (CBT), or a combination of antidepressant medication plus CBT.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| fluoxetine | Drug | |||
| sertraline | Drug | |||
| citalopram | Drug | |||
| escitalopram | Drug | |||
| bupropion | Drug | |||
| mirtazapine | Drug | |||
| venlafaxine | Drug | |||
| lithium |
Inclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Laurence Greenhill, MD | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Johns Hopkins University | Baltimore | Maryland | 21287 | United States | ||
| New York University Child Study Center |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19730274 | Derived | Brent DA, Greenhill LL, Compton S, Emslie G, Wells K, Walkup JT, Vitiello B, Bukstein O, Stanley B, Posner K, Kennard BD, Cwik MF, Wagner A, Coffey B, March JS, Riddle M, Goldstein T, Curry J, Barnett S, Capasso L, Zelazny J, Hughes J, Shen S, Gugga SS, Turner JB. The Treatment of Adolescent Suicide Attempters study (TASA): predictors of suicidal events in an open treatment trial. J Am Acad Child Adolesc Psychiatry. 2009 Oct;48(10):987-996. doi: 10.1097/CHI.0b013e3181b5dbe4. | |
| 19730273 |
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| Drug |
| Cognitive Behavioral Therapy | Behavioral |
| New York |
| New York |
| 10016 |
| United States |
| Columbia University at the New York State Psychiatric Institute | New York | New York | 10032 | United States |
| Duke University Medical Center | Durham | North Carolina | 27705 | United States |
| University of Pittsburgh - Western Psychiatric Institute and Clinic | Pittsburgh | Pennsylvania | 15213 | United States |
| University of Texas, Southwestern Medical Center | Dallas | Texas | 75235 | United States |
| Stanley B, Brown G, Brent DA, Wells K, Poling K, Curry J, Kennard BD, Wagner A, Cwik MF, Klomek AB, Goldstein T, Vitiello B, Barnett S, Daniel S, Hughes J. Cognitive-behavioral therapy for suicide prevention (CBT-SP): treatment model, feasibility, and acceptability. J Am Acad Child Adolesc Psychiatry. 2009 Oct;48(10):1005-1013. doi: 10.1097/CHI.0b013e3181b5dbfe. |
| ID | Term |
|---|---|
| D003863 | Depression |
| D013406 | Suicide, Attempted |
| D019263 | Dysthymic Disorder |
| ID | Term |
|---|---|
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
| D013405 | Suicide |
| D016728 | Self-Injurious Behavior |
| D003866 | Depressive Disorder |
| D019964 | Mood Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D005473 | Fluoxetine |
| D020280 | Sertraline |
| D015283 | Citalopram |
| D000089983 | Escitalopram |
| D016642 | Bupropion |
| D000078785 | Mirtazapine |
| D000069470 | Venlafaxine Hydrochloride |
| D008094 | Lithium |
| D015928 | Cognitive Behavioral Therapy |
| ID | Term |
|---|---|
| D011437 | Propylamines |
| D000588 | Amines |
| D009930 | Organic Chemicals |
| D015057 | 1-Naphthylamine |
| D009281 | Naphthalenes |
| D011084 | Polycyclic Aromatic Hydrocarbons |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D011083 | Polycyclic Compounds |
| D009570 | Nitriles |
| D001572 | Benzofurans |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |
| D011427 | Propiophenones |
| D007659 | Ketones |
| D003984 | Dibenzazepines |
| D006575 | Heterocyclic Compounds, 3-Ring |
| D003511 | Cyclohexanols |
| D000441 | Hexanols |
| D005233 | Fatty Alcohols |
| D000438 | Alcohols |
| D010627 | Phenethylamines |
| D005021 | Ethylamines |
| D003510 | Cyclohexanes |
| D003516 | Cycloparaffins |
| D006840 | Hydrocarbons, Alicyclic |
| D008055 | Lipids |
| D008672 | Metals, Alkali |
| D004602 | Elements |
| D007287 | Inorganic Chemicals |
| D019565 | Metals, Light |
| D008670 | Metals |
| D001521 | Behavior Therapy |
| D011613 | Psychotherapy |
| D004191 | Behavioral Disciplines and Activities |
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