Safety and Efficacy Study of RTS,S AS02A/AS01B Vaccine to Prevent Malaria

Dbl-Blind, Rand Phase 1/2a Human Challenge Study, to Eval Safety, Reactogenicity, Immunogenicity and Preliminary Efficacy After Sporozoite Challenge/Rechallenge of Vaccines Containing RTS,S

This is a double blinded study where 2 test vaccines will be evaluated to see if they protect persons who have never had malaria against malaria infection when bitten by mosquitoes.

Inclusion Criteria:

• Be in good general health
• Be able to participate for 4-15 months

Exclusion Criteria:

• Pregnant or planning pregnancy
• History of malaria or exposure to malaria in past 12 months
• Received an investigational malaria vaccine
• Past history of allergic reaction to previous immunization
• Positive blood tests for HIV and specific types of hepatitis