Genetic Registry for Rheumatoid Arthritis

Genetics of Rheumatoid Arthritis Registry

Many genes are thought to contribute to rheumatoid arthritis (RA). This study will attempt to identify genes that may contribute to RA.

The identification of genes for complex disorders such as RA requires large numbers of genetically informative families. This study enrolls people diagnosed with with RA and their families.

This study will enroll 1000 RA patients and their parents. Participants with RA will be evaluated at his or her doctor's office or other location convenient for the participant. Participants will have a brief phone interview with a study coordinator and a blood sample will be obtained. Disease evaluation will be done at one visit and will include confirmation of diagnosis, a 28 joint count, joint alignment and mobility score (JAMS) and administration of a health assessment questionnaire.

Inclusion Criteria:

• Adult onset RA
• Diagnosis of RA made between 18 and 60 years old
• Both parents alive and willing to participate
• Parents may have diagnosis of RA (affected) or be unaffected

Exclusion Criteria:

• Inflammatory bowel disease
• Lupus
• Psoriatic arthritis