A placebo controlled study evaluating the effectiveness of medication in preventing winter depressive episodes in patients with a history of Seasonal Affective Disorder

A 7-Month Multicenter, Parallel, Double-Blind, Placebo-Controlled Comparison of 150-300mg/day of Extended-release Bupropion Hydrochloride and Placebo for the Prevention of Seasonal Depressive Episodes in Subjects with a History of Seasonal Affective Disorder Followed by an 8-week Observational Follow-up Phase

Inclusion Criteria:

• History of Major Depressive Disorder (MDD) with a seasonal pattern.

Exclusion Criteria:

• Current or past history of seizure disorder or brain injury.
• History or current diagnosis of anorexia nervosa or bulimia.
• Recurrent summer depression more frequently than winter depression.
• Primary diagnosis of panic disorder, Obsessive Compulsive Disorder (OCD), Post-traumatic Stress Disorder(PTSD), acute distress disorder, bipolar II disorder or other psychotic disorders.
• Initiated psychotherapy within the last 3 months.