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| ID | Type | Description | Link |
|---|---|---|---|
| R01DK049779 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | NIH |
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Overweight premenopausal Black and White women are randomized to either diet-only, diet+aerobic or diet+resistance exercise training. Diet/behavior intervention, with or without the aerobic or resistance exercise training, will be provided throughout the 18 months of study. Major outcomes will include measures of perceived and physiologic difficulty of exercise (cardiac, ventilatory, electromyographic responses to standardized exercise tasks); aerobic fitness; strength fitness; and spontaneous free-living energy expenditure (all derived from doubly labeled water). The results will provide insight into the effectiveness of, and the mechanisms by which, different types of exercise training can improve physical fitness, spontaneous engagement in physical activities of daily living and, in turn, weight-loss maintenance.
Overweight premenopausal Black and White women are randomized to either diet-only, diet+aerobic or diet+resistance exercise training. Diet/behavior intervention, with or without the aerobic or resistance exercise training, will be provided throughout the 18 months of study. Major outcomes will include measures of perceived and physiologic difficulty of exercise (cardiac, ventilatory, electromyographic responses to standardized exercise tasks); aerobic fitness; strength fitness; and spontaneous free-living energy expenditure (all derived from doubly labeled water). The results will provide insight into the effectiveness of, and the mechanisms by which, different types of exercise training can improve physical fitness, spontaneous engagement in physical activities of daily living and, in turn, weight-loss maintenance.
Time of initial weight loss was defined as the time needed to reach the goal of 25 kg/m2 BMI. The women will then be evaluated one year after this time and the amount of weight gain will be determined.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Diet only | Active Comparator |
| |
| Diet plus aerobic exercise | Experimental |
| |
| Diet plus resistance exercise | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Diet | Behavioral |
| ||
| Aerobic exercise |
| Measure | Description | Time Frame |
|---|---|---|
| Weight loss | 6 months | |
| Change in weight after initial weight loss | Time of initial weight loss determined by days to reach BMI <= 25 (maximum 6 months) | 12 months after initial weight loss (maximum 18 months after randomization) |
| Measure | Description | Time Frame |
|---|---|---|
| Insulin sensitivity | 6 months post baseline | |
| Insulin sensitivity | 18 months post baseline | |
| Change in visceral fat |
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| Name | Affiliation | Role |
|---|---|---|
| Gary R Hunter, PhD | University of Alabama at Birmingham | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35294 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25606816 | Result | Hunter GR, Fisher G, Neumeier WH, Carter SJ, Plaisance EP. Exercise Training and Energy Expenditure following Weight Loss. Med Sci Sports Exerc. 2015 Sep;47(9):1950-7. doi: 10.1249/MSS.0000000000000622. | |
| 19816413 | Result | Hunter GR, Brock DW, Byrne NM, Chandler-Laney PC, Del Corral P, Gower BA. Exercise training prevents regain of visceral fat for 1 year following weight loss. Obesity (Silver Spring). 2010 Apr;18(4):690-5. doi: 10.1038/oby.2009.316. Epub 2009 Oct 8. |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D004032 | Diet |
| D015444 | Exercise |
| D055070 | Resistance Training |
| ID | Term |
|---|---|
| D009747 | Nutritional Physiological Phenomena |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D009043 | Motor Activity |
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| Behavioral |
|
| Resistance exercise | Behavioral |
|
| 6 months post baseline |
| Change in visceral fat | 18 months post baseline |
| Change in cholesterol | 6 months post baseline |
| Change in cholesterol | 18 months post baseline |
| Change in triglycerides | 6 months post baseline |
| Change in triglycerides | 18 months post baseline |
| Change in resting energy expenditure | 6 months post baseline |
| Change in resting energy expenditure | 18 months post baseline |
| 40898644 | Derived | Bartholomew CL, Martins C, Gower B. The Role of Insulin Sensitivity in Lean Mass Changes During Weight Loss With or Without Exercise. Obesity (Silver Spring). 2025 Nov;33(11):2103-2111. doi: 10.1002/oby.70010. Epub 2025 Sep 2. |
| 40110172 | Derived | Martins C, Gower BA, Hunter GR. Changes in Trunk, but Not Limb, Lean Body Mass Contribute to Variability in Metabolic Adaptation Following Weight Loss. Obes Sci Pract. 2025 Mar 19;11(2):e70054. doi: 10.1002/osp4.70054. eCollection 2025 Apr. |
| 35797356 | Derived | Martins C, Gower BA, Hunter GR. Association between Fat-Free Mass Loss after Diet and Exercise Interventions and Weight Regain in Women with Overweight. Med Sci Sports Exerc. 2022 Dec 1;54(12):2031-2036. doi: 10.1249/MSS.0000000000002992. Epub 2022 Jul 8. |
| 32386226 | Derived | Martins C, Gower BA, Hill JO, Hunter GR. Metabolic adaptation is not a major barrier to weight-loss maintenance. Am J Clin Nutr. 2020 Sep 1;112(3):558-565. doi: 10.1093/ajcn/nqaa086. |
| 21820136 | Derived | Brock DW, Tompkins CL, Fisher G, Hunter GR. Influence of resting energy expenditure on blood pressure is independent of body mass and a marker of sympathetic tone. Metabolism. 2012 Feb;61(2):237-41. doi: 10.1016/j.metabol.2011.06.019. Epub 2011 Aug 4. |
| 19816412 | Derived | Brock DW, Chandler-Laney PC, Alvarez JA, Gower BA, Gaesser GA, Hunter GR. Perception of exercise difficulty predicts weight regain in formerly overweight women. Obesity (Silver Spring). 2010 May;18(5):982-6. doi: 10.1038/oby.2009.318. Epub 2009 Oct 8. |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
| D005081 | Exercise Therapy |
| D012046 | Rehabilitation |
| D000359 | Aftercare |
| D003266 | Continuity of Patient Care |
| D005791 | Patient Care |
| D013812 | Therapeutics |
| D026741 | Physical Therapy Modalities |
| D064797 | Physical Conditioning, Human |