Pemetrexed Plus Gemcitabine in Metastatic Breast Cancer Patients After Receiving Taxane Therapy

Phase II Trial of Alimta (Pemetrexed) and Gemzar (Gemcitabine) in Metastatic Breast Cancer Patients Who Have Received Prior Taxane Therapy

The purpose of the study is to determine if the two drugs can help patients feel better while causing the tumor to become smaller or disappear; evaluate the safety of giving both pemetrexed and gemcitabine in patients with advanced breast cancer.

Inclusion Criteria:

• Must have received prior chemotherapy with Taxol (paclitaxel) or Taxotere (docetaxel).
• Less than 3 different chemotherapy treatments for metastatic disease.
• Prior treatment with hormonal and/or radiation therapy.
• Must have disease that can be measured.
• Must be able to take care of self needs for example personal hygiene

Exclusion Criteria:

• Must not be pregnant or breast-feeding.
• Cancer that has spread to the brain.
• Treatment with Gemcitabine or Pemetrexed
• Unable to take folic acid or Vitamin B12
• Treatment for another cancer within the last 5 years