The purpose of this study is to evaluate the efficacy and safety of quetiapine in the treatment of a major depressive episode in patients with bipolar disorder.

Inclusion Criteria:

• Written Informed Consent;
• Bipolar disorder with most recent episode depressed;
• Outpatient status

Exclusion Criteria:

• Patients with a current Axis I disorder other than bipolar disorder within 6 months of screening;
• Patients whose current episode of depression exceeds 12 months or is less than 4 weeks