Role of Epidermal Growth Factor (EGF) in Development of Necrotizing Enterocolitis

Role of Epidermal Growth Factor (EGF) in Development of Necrotizing Enterocolitis

Necrotizing enterocolitis (NEC) is a serious gastrointestinal disorder that primarily affects preterm infants. About 10% of babies less than 32 weeks gestation at birth will develop it. Overall, 30% of babies who develop NEC will die from it, with many others developing long term gastrointestinal problems. The most important factor in its development is a premature intestinal tract. Epidermal growth factor (EGF) is an important growth factor in the development and maintenance of the gastrointestinal tract. This study will look for a relationship between EGF levels in premature babies and the development of NEC.

Inclusion Criteria:

• Gestational Age greater than 23 weeks at birth
• Birth weight greater than 500 grams
• Age less than 72 hours of life