Comparison of Teriparatide With Alendronate for Treating Glucocorticoid-Induced Osteoporosis

Comparison of the Effects of Teriparatide With Those of Alendronate Sodium on Lumbar Spine Bone Mineral Density in Glucocorticoid-Induced Osteoporosis

Osteoporosis is a condition in which the amount of bone is reduced, the bones are weak, and there is an increased risk for fractures. Glucocorticoids (such as prednisone) are prescribed to treat a large number of conditions such as arthritis and asthma. When taken for several months or longer, glucocorticoids can cause bone loss and lead to a form of osteoporosis called "glucocorticoid-induced osteoporosis." This study compared the effects of teriparatide, the study drug, with alendronate, an approved drug for treating glucocorticoid-induced osteoporosis.

Inclusion Criteria:

• Men or women age 21 years or older
• Taking on average 5.0 mg/day prednisone or equivalent for at least 3 months prior to screening

Exclusion Criteria:

• Taking bisphosphonates within past 6 months
• More than 30 micrograms/day of estradiol or equivalent in past 3 months
• History of alcoholism or drug abuse in past year
• Pregnant women or nursing mothers