To evaluate the efficacy of dexmethylphenidate (d-MPH) in the treatment of chemotherapy-related fatigue in adult cancer subjects.

• Diagnosis of cancer, excluding primary or metastatic brain tumors.
• Treated with a minimum of four cycles of a cytotoxic chemotherapy, the last chemotherapy treatment must have been completed at least 2 months prior to study entry.
• Physical/neurological examination consistent with the absence of a focal neurological deficit
• Women of childbearing potential (WCBP) must have a negative serum or urine pregnancy test. In addition, sexually active WCBP must agree to use adequate contraceptive methods (oral, injectable, or implantable hormonal contraceptive; tubal ligation; intra-uterine device; barrier contraceptive with spermicide; or vasectomized partner).
• Subjects must be able to adhere to the protocol requirements.
• Subjects must understand and voluntarily sign an informed consent document.
• Subjects must be a native English speaker or fluent in English, and have at least an eighth grade education.