This study will evaluate the drop in viral load over 10 days of treatment with S-1360 versus placebo in HIV-infected patients who have not previously taken anti-HIV medications.

Inclusion Criteria:

• No prior HIV medications.
• HIV infection with viral load >400-50,000 copies/mL.
• CD4 cell count >50 cells/mm.

Exclusion Criteria:

• Patients requiring medications that cannot be interrupted for the duration of the study.
• Abnormal ECG or other chronic health conditions as noted on screening physical exam.
• Previous participation in an experimental drug trial(s) within 30 days of the screening visit for this study.