Measurement Of Serum Levels Of Two Antiepileptic Drugs During Conversion In Patients With Epilepsy

A Multicenter, Open-Label Conversion of Valproate Monotherapy to Lamotrigine Monotherapy in Patients With Epilepsy

This study includes patients 16 years of age or older with a confident diagnosis of epilepsy who are currently treated with an antiepileptic drug (AED) monotherapy but require a change in therapy due to inadequate seizure control and/or unacceptable side effects.

INCLUSION CRITERIA:

• 16 years old or older.
• Have confident diagnosis of epilepsy.
• Have been on the medication valproate for at least 3 months and is currently on a stable daily dose.
• Male or female; females of child-bearing potential must have negative pregnancy test at screen and must agree to use an acceptable birth control method.

EXCLUSION CRITERIA:

• A history of hypersensitivity to the drug being studied.
• Currently being treated with or has been treated in the past with the drug being studied.
• Undergoing polytherapy treatment with the medication valproate and one or more other antiepileptic drug(s).
• If undergoing treatment with vagal nerve stimulation, has had device implanted more than 30 days prior to enrollment.
• Has taken an investigational drug or the medication Felbatol within the previous 30 days.
• Is abusing alcohol and/or other substances.