Efficacy and Safety of PG-530742 in the Treatment of Mild to Moderate Knee Osteoarthritis

Efficacy and Safety of PG-530742 in the Treatment of Mild to Moderate Knee Osteoarthritis

Matrix metalloproteinases (MMPs) have been implicated in the cartilage degradation. PG-530742 inhibits some MMPs, potentially limiting cartilage degradation and disease progression. This study will test the efficacy and safety of PG-530742 in the treatment of mild to moderate knee osteoarthritis.

Matrix metalloproteinases have been implicated in the cartilage degradation that occurs in osteoarthritis. PG-530742 inhibits some of these matrix metalloproteinases, thus potentially limiting cartilage degradation and disease progression. This study will test the efficacy and safety of PG-530742 in the treatment of mild to moderate knee osteoarthritis.

Inclusion Criteria:

• mild to moderate knee osteoarthritis confirmed by a radiographic technique.

Exclusion Criteria:

• secondary knee osteoarthritis;
• diseases other than osteoarthritis that could cause knee pain;
• any disease or intervention (surgery, intra-articular injection) that would have an impact on knee pain or mobility;
• drugs that act potentially on the bone or cartilage component of the knee joint.