Phase 2 Study of TLK286 Administered Weekly in Advanced Non-Small Cell Lung Cancer

The purpose of this study is to determine the effectiveness of TLK286 in the treatment of advanced non-small cell lung cancer.

Inclusion Criteria:

• Histologic or cytologic diagnosis of non-small cell lung carcinoma
• Progressed while on or after treatment on platinum-based regimen
• Patients may not have had more than one prior cytotoxic chemotherapy regimen
• Stage IV or IIIB
• Age at least 18 years
• Adequate liver and kidney function
• Adequate bone marrow function

Exclusion Criteria:

• Pregnancy or lactation
• Unstable medical conditions
• Chemotherapy, hormonal therapy, radiotherapy, radiopharmaceuticals or immunotherapy within 3 weeks of TLK286
• CNS metastasis unless controlled by treatment