The purposes of this study are to determine whether an investigational drug can help patients suffering from major depression with pain symptoms, and gather data on the safety of the investigational drug including any side effects that might be associated with it.

Inclusion Criteria:

• You must be suffering from symptoms of depression for at least the past 2 weeks (sadness, loss of interest in daily activities, feelings of hopelessness or guilt, sleeplessness or lack of energy)
• You must have pain symptoms with no known cause, such as unexplainable, head, chest, or back pain, overall aches and pains, or other unexplainable pains.
• You need to be available to visit a doctor's office about once a week for 10 weeks.

Exclusion Criteria:

• You are a woman and are pregnant or breastfeeding.
• You have a current or previous diagnosis of bipolar disorder, schizophrenia, or other psychotic disorder.
• You have had a primary diagnosis of an anxiety disorder within the past 6 months.
• You have a history of alcohol or drug dependence or abuse within the past 6 months.
• You have a serious medical illness.