Patients with bone metastases or bone lesions caused by breast cancer, multiple myeloma or prostate cancer will be treated with IV Zometa in a 15 minute infusion. Pain will be evaluated, as well as time in chair, quality of life and safety of Zometa.

Inclusion Criteria

• Signed informed consent
• Greater than 18 years of age
• Proof of breast cancer, multiple myeloma or prostate cancer
• Diagnosis of at least one cancer-related bone lesion
• If patient is of child-bearing potential, negative pregnancy test and on a medically recognized form of contraception
• ECOG performance status of 0,1 or 2
• Ability to read, understand and write English or Spanish language
• Normal renal function
• Corrected serum calcium equal to or greater than 8mg/dl Exclusion Criteria
• clinically symptomatic brain metastases
• hypersensitivity to Zometa or other bisphosphonates
• pregnant or lactating