Assessment of Clinical and Neuroradiologic Evidence of Methotrexate Leukoencephalopathy in Children Treated on POG 9605 and 9201
Assessment of Clinical and Neuroradiologic Evidence of Methotrexate Leukoencephalopathy in Children Treated on POG 9605 and 9201
RATIONALE: Assessing the effects of methotrexate on brain function in children may improve the ability to plan treatment and decrease side effects.
PURPOSE: Clinical trial to compare brain function of children who have been previously treated with methotrexate.
OBJECTIVES:
OUTLINE: This is a multicenter study.
More than 3 years after completion of therapy, patients undergo 9 different tests to assess intelligence, memory, learning, attention, concentration, processing of information, functioning, and visual-motor integration. Patients also undergo MRI of the head.
PROJECTED ACCRUAL: A total of 30-54 patients previously treated on protocol POG-9201 will be accrued for this study. A total of 60-108 patients previously treated on protocol POG-9605 will be accrued for this study.
DISEASE CHARACTERISTICS:
Previously enrolled on POG-9201 or POG-9605
Eligible for the therapeutic study
Completed therapy by 12/31/2000
No CNS3 at diagnosis
No relapsed disease
PATIENT CHARACTERISTICS:
Age:
Performance status:
Life expectancy:
Hematopoietic:
Hepatic:
Renal:
Other:
PRIOR CONCURRENT THERAPY:
Biologic therapy
Chemotherapy
Endocrine therapy
Radiotherapy
Surgery
Other
Little Rock, Arkansas 72205, United States
Miami, Florida 33136, United States
Boston, Massachusetts 02111, United States
Grosse Pointe Woods, Michigan 48236, United States
Albuquerque, New Mexico 87131-5636, United States
Charlotte, North Carolina 28232-2861, United States
Winston-Salem, North Carolina 27157-1096, United States
Charleston, South Carolina 29425, United States