Selected individuals suspected of having or with prior biopsy proof of malignant disease will be seen in the Urologic Oncology Branch, NCI. Blood samples may be collected at the time of the initial visit and at periodic intervals during the course of the disease. These samples will be stored in the tissue bank of the Urologic Oncology Branch. Aliquots of malignant and normal tissue will be collected at the time of surgery and stored in the tissue bank, Urologic Oncology Branch, NCI. These materials will be used in the research efforts of the Urologic Oncology Branch, NCI.

Background

Kidney, prostate, bladder, testis and penile cancer account for 22% of cancers diagnosed in the United States and are responsible for 10% of cancer deaths each year in the U.S. Understanding the genes and gene pathways that cause genitourinary malignancies will provide the foundation for the development of targeted therapeutic agents for patients affected with these cancers. Since 1982 investigators in the Urologic Oncology Branch have been studying the genetic basis of urologic cancers. The identification of the genes for cancer of the kidney has led to the approval by the FDA of a number of new agents for patients with advanced disease. It is our goal to study the cancer gene pathways of genitourinary malignancies in order to further understand the cancer gene pathways that cause these diseases.

Objectives

• Collection of benign and malignant tissue from patients with known or suspected cancer
• Collection of benign and malignant tissue from patients with rare inherited conditions associated with an increased risk for kidney cancer
• Determine the molecular genetic differences between normal and tumorigenic tissues
• Investigate the categories of genes/ biochemical pathways such as those that influence the cell cycle, angiogenesis, metabolic changes, and metastatic potential
• Examine protein expression and bioimmunoassays investigating potential genetic markers
• Investigate cellular/biochemical response to existing and novel therapeutic agents.
• Investigate quality of life in men who have prostate cancer
• Investigate molecular genetic basis of urologic malignancies
• Examine cell free DNA and circulating tumor DNA for cancer gene mutations

Eligibility

• Individuals with biopsy-proven malignant disease
• Individuals suspected of having malignant disease
• Individuals with known or suspected inherited urologic malignant disorder
• A relative (related by blood) of an individual with a confirmed or suspected diagnosis of an inherited genitourinary disorder or malignancy
• Family members of patients with a DNA variant

Design

• Participants will be screened for eligibility in the Urologic Oncology Branch Clinic
• Blood and urine samples may be obtained
• Normal and malignant tissue may be collected from participants undergoing clinically indicated surgical procedures
• Basic scientific research will be performed on collected specimens
• Participants will have the option to be contacted if a result is detected that would affect their health and they will be given the opportunity to be evaluated and re-tested on an IRB approved protocol if available
• Germline and somatic whole genome exome sequencing may be performed

• INCLUSION CRITERIA:
• Individuals with biopsy-proven malignant disease
• Individuals suspected of having a malignant disease
• Individuals who have or are suspected of having an inherited genitourinary malignant disorder
• Participants must be >= 2 years of age
• A relative (related by blood) of an individual with a confirmed or suspected diagnosis of a malignant disease or an inherited genitourinary malignant disorder.
• All participants and parents/guardians, for children younger than 18 years of age, must sign an informed consent document indicating their understanding of the investigational nature and the risks of this study before any protocol related studies are performed.

EXCLUSION CRITERIA:

-Individuals whose co-morbidities preclude surgical intervention.

1. Individuals with biopsy-proven malignant disease 2. Individuals suspected of having malignant disease 3. Individuals with known or suspected urologic malignant disorders who have clinically indicated urologic or non-urologic surgical lesion 4. Family members of individuals suspected of having an inherited genitourinary malignancy 5. Family members of individuals with a DNA variant

All IPD recorded in the medical record will be shared with intramural investigators upon request. @@@@@@In addition, all large scale genomic sequencing data will be shared with subscribers to dbGaP.

Clinical data available during the study and indefinitely.@@@@@@Genomic data are available once genomic data are uploaded per protocol GDS plan for as long as database is active.

Clinical data will be made available via subscription to BTRIS and with the permission of the study PI.@@@@@@Genomic data are made available via dbGaP through requests to the data custodians.