The Impact of Pediatric Marrow Transplantation on Late Pulmonary Function
The Impact of Pediatric Marrow Transplantation on Late Pulmonary Function
RATIONALE: Assessing the long-term effects of bone marrow transplant on lung function in patients may improve the ability to plan treatment.
PURPOSE: This clinical trial studies lung function in pediatric patients who have undergone bone marrow transplant.
OBJECTIVES:
OUTLINE: Patients undergo respiratory history, signs and symptoms assessment, pulmonary function tests (PFT) including spirometry, lung volumes, and diffusion, oxygen saturation by pulse oximetry, and height measurement.
Patients are assessed at 5-10 years, 10-15 years, and over 15 years after bone marrow transplantation. Patients with abnormal PFTs are assessed at more frequent intervals as clinically indicated.
PROJECTED ACCRUAL: Approximately 280 patients will be accrued for this study.
DISEASE CHARACTERISTICS:
Patients who have undergone bone marrow transplantation for hematologic malignancy at least 5 years ago
Received prior allogeneic, unrelated donor, syngeneic, or autologous bone marrow transplantation
Able to perform pulmonary function tests
PATIENT CHARACTERISTICS:
Age:
Performance status:
Life expectancy:
Hematopoietic:
Hepatic:
Renal:
PRIOR CONCURRENT THERAPY:
Biologic therapy:
Chemotherapy:
Endocrine therapy:
Radiotherapy:
Surgery:
Other: