The purpose of this study is to evaluate the safety of tenofovir disoproxil fumarate (tenofovir DF) in combination with other anti-HIV drugs in patients who have participated in other tenofovir DF studies (GS-98-902 or GS-99-907), are able to tolerate the drug at different doses, and may benefit from having tenofovir DF treatment.

Patients take tenofovir DF in combination with other antiretrovirals.

Inclusion Criteria

Patients may be eligible for this study if they:

• Have completed another study on tenofovir DF without toxicity.
• Are willing to use intrauterine or effective barrier methods of birth control, both men and women, during the study and for 30 days following tenofovir DF treatment.

Exclusion Criteria

Patients will not be eligible for this study if they:

• Are taking drugs that may damage the kidney (nephrotoxic) including aminoglycoside antibiotics, amphotericin B, cidofovir, cisplatin, foscarnet, IV pentamidine, vancomycin, and oral or IV ganciclovir.
• Are taking agents that affect kidney function, such as probenecid.
• Are receiving systemic chemotherapy.
• Are taking systemic corticosteroids.
• Are taking experimental drugs except those that are approved by Gilead.
• Are currently participating in the GS-99-908 or GS-00-912 (expanded access) studies.
• Are pregnant or breast-feeding.