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| ID | Type | Description | Link |
|---|---|---|---|
| R01HL057826 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Heart, Lung, and Blood Institute (NHLBI) | NIH |
To identify the role of salt-sensitivity of blood pressure in the pathogenesis of hypertension.
DESIGN NARRATIVE:
Approximately 498 of 750 normal and hypertensive subjects who were carefully characterized in terms of blood pressure response to salt loading and depletion in the late 1970s were re-examined to identify physiological factors contributing to salt-sensitivity of blood pressure. This helped to confirm preliminary observations suggesting that salt sensitivity in normotensive subjects predicted the subsequent development of hypertension with aging. In addition, longitudinal observations in hypertensive patients and in normotensives helped to determine whether salt-sensitivity or salt-resistance of blood pressure were associated with differences in the risk for development of specific forms of cardiovascular disease (stroke, angina, myocardial infarction, congestive heart failure), renal and metabolic (diabetes mellitus) disorders.
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No eligibility criteria
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| Name | Affiliation | Role |
|---|---|---|
| Myron Weinberger | Indiana University-Purdue University |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 11230313 | Background | Weinberger MH, Fineberg NS, Fineberg SE, Weinberger M. Salt sensitivity, pulse pressure, and death in normal and hypertensive humans. Hypertension. 2001 Feb;37(2 Pt 2):429-32. doi: 10.1161/01.hyp.37.2.429. | |
| 11864792 | Background | Weinberger M, Weinberger MH, Fineberg N, Fineberg SE, Wagner U. Long-term follow-up of participants in clinical studies. J Clin Epidemiol. 2002 Mar;55(3):230-4. doi: 10.1016/s0895-4356(01)00437-1. |
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| ID | Term |
|---|---|
| D002318 | Cardiovascular Diseases |
| D006331 | Heart Diseases |
| D006973 | Hypertension |
| D000787 | Angina Pectoris |
| D020521 | Stroke |
| D009203 | Myocardial Infarction |
| D003920 | Diabetes Mellitus |
| D006333 | Heart Failure |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D017202 | Myocardial Ischemia |
| D002637 | Chest Pain |
| D010146 | Pain |
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| 12160189 | Background | Weinberger MH, Fineberg NS, Fineberg SE. The influence of blood pressure and carbohydrate tolerance on vascular compliance in humans. Am J Hypertens. 2002 Aug;15(8):678-82. doi: 10.1016/s0895-7061(02)02955-2. |
| 12147930 | Background | Weinberger MH. Salt sensitivity is associated with an increased mortality in both normal and hypertensive humans. J Clin Hypertens (Greenwich). 2002 Jul-Aug;4(4):274-6. doi: 10.1111/j.1524-6175.2002.00924.x. |
| 11991223 | Background | Weinberger MH, Fineberg NS, Fineberg SE. Effects of age, race, gender, blood pressure, and estrogen on arterial compliance. Am J Hypertens. 2002 Apr;15(4 Pt 1):358-63. doi: 10.1016/s0895-7061(02)02261-6. |
| D009461 |
| Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D007238 | Infarction |
| D007511 | Ischemia |
| D010335 | Pathologic Processes |
| D009336 | Necrosis |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |