Study of Genotype and Phenotype in Patients With Alpha 1-Antitrypsin Deficiency

OBJECTIVES:

I. Establish cell lines from patients with alpha 1-antitrypsin deficiency in order to examine genetic traits that predispose to liver injury.

PROTOCOL OUTLINE:

Patients undergo blood draw and skin biopsy. Cells are isolated from patients' blood and skin, cell lines are established, and genetic traits are examined.

• Alpha 1-antitrypsin deficiency