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| ID | Type | Description | Link |
|---|---|---|---|
| CHP-5R01HD29201-03 |
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| Name | Class |
|---|---|
| Children's Hospital of Philadelphia | OTHER |
OBJECTIVES:
I. Assess the efficacy and safety of antenatal administration of thyrotropin-releasing hormone to women in premature labor to improve pulmonary outcomes in preterm infants.
PROTOCOL OUTLINE: This is a randomized, double blind, multicenter study. Patients are randomized to receive antenatal thyrotropin-releasing hormone or placebo.
Patients receive thyrotropin-releasing hormone or placebo intravenously over 20 minutes every 8 hours for 4 doses.
Infants are assessed for survival and chronic lung disease until day 28 after birth, and again at 36 postmenstrual weeks.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| thyrotropin-releasing hormone | Drug |
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| Name | Affiliation | Role |
|---|---|---|
| Roberta A. Ballard | Children's Hospital of Philadelphia | Study Chair |
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| ID | Term |
|---|---|
| D012128 | Respiratory Distress Syndrome |
| D012140 | Respiratory Tract Diseases |
| D007232 | Infant, Newborn, Diseases |
| D035583 | Rare Diseases |
| ID | Term |
|---|---|
| D008171 | Lung Diseases |
| D012120 | Respiration Disorders |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D013973 | Thyrotropin-Releasing Hormone |
| ID | Term |
|---|---|
| D010906 | Pituitary Hormone-Releasing Hormones |
| D007028 | Hypothalamic Hormones |
| D036361 | Peptide Hormones |
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
| D009479 | Neuropeptides |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |
| D009842 | Oligopeptides |
| D009419 | Nerve Tissue Proteins |
| D011506 | Proteins |
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