OBJECTIVES: I. Assess pituitary size and anatomic configuration by magnetic resonance imaging (MRI) in 4 affected dwarfs in the province of Sindh, Pakistan.

II. Evaluate ultradian growth hormone (GH) secretory patterns in 4 affected dwarfs.

PROTOCOL OUTLINE: Pituitary size and anatomy and growth hormone response are evaluated.

All patients undergo MRI of the pituitary fossa on day 1. On day 2, homozygous patients receive a slow infusion of normal saline with blood sampling every 10 minutes.

• Familial Dwarfism of Sindh
• Severe short stature but proportionate without dysmorphic features
• Normal body size and weight at birth
• Bone age is severely delayed
• Puberty is somewhat delayed (age 15-16)
• Fertility present in at least 3 dwarfs