The Clinical and Pathological Significance of Allelic Imbalance of 8p in Patients With Colorectal Cancer
The Clinical and Pathological Significance of Allelic Imbalance of 8p in Patients With Colorectal Cancer
RATIONALE: Genetic studies may help in understanding the genetic processes that cause some types of cancer.
PURPOSE: Genetic trial to study certain genes of patients who have stage II or stage III colon cancer.
OBJECTIVES:
OUTLINE: Matched normal and tumor DNA is analyzed for 8p allelic imbalance with at least 8 markers: D8S262 and D8S1825 localized to 8p23, D8S254 and D8S261 at 8p22, D8S560 and D8S136 at 8p21, and D8S1820 and D8S283 at 8p12. Normal/tumor tissue pairs are used for fine mapping studies.
DISEASE CHARACTERISTICS:
PATIENT CHARACTERISTICS:
Age
Surrey, British Columbia V3V 1Z2, Canada
St. John's, Newfoundland and Labrador A1B 3V6, Canada
North York, Ontario M2K 1E1, Canada
Toronto, Ontario M5S 1B6, Canada
Ste-Foy, Quebec G1V 4G5, Canada