To investigate the potential benefit of providing passive immunity with hyperimmune anti-HIV human serum.

Inclusion Criteria

Patients must have:

• Proof of HIV infection.
• Diagnosis of asymptomatic HIV infection or early AIDS related complex (ARC) with no zidovudine (AZT) or other anti-HIV therapy. OR a diagnosis of AIDS and = or > 3 months of AZT therapy.

Exclusion Criteria

Co-existing Condition:

Patients with the following conditions or symptoms are excluded:

• HIV-induced neurological disease.
• IgA negative.

Concurrent Medication:

Excluded:

• Immunomodulating agents.
• Steroids.
• Interferons.

Patients with the following are excluded:

• Active substance abuse.
• Use of immunomodulating drugs such as steroids or interferons.
• HIV-induced neurological disease.
• IgA negative.

Required with a diagnosis of AIDS:

• = or > 3 months of zidovudine (AZT) therapy.

Active substance abuse.