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To identify patterns of zidovudine ( AZT ) susceptibility among mother/infant pairs with perinatal HIV transmission.
Most HIV-infected infants acquire their disease via perinatal transmission. Since transmission of HIV-resistant strains to infants could alter the course of disease and response to currently recommended treatment, a study to assess the patterns of AZT susceptibility among mother/infant pairs with perinatal transmission is essential to delineate future therapeutic strategies.
Most HIV-infected infants acquire their disease via perinatal transmission. Since transmission of HIV-resistant strains to infants could alter the course of disease and response to currently recommended treatment, a study to assess the patterns of AZT susceptibility among mother/infant pairs with perinatal transmission is essential to delineate future therapeutic strategies.
HIV-infected pregnant women are enrolled at 20-36 weeks gestation. Patients have blood drawn for HIV culture at study entry and at delivery. Infants have blood drawn for HIV culture at delivery and at 1, 3, 6, and 18 months of age.
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Inclusion Criteria
Prior Medication: Required:
Patients must have:
Exclusion Criteria
Co-existing Condition:
Patients with the following symptoms or conditions are excluded:
Concurrent Medication:
Excluded:
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| Name | Affiliation | Role |
|---|---|---|
| Bardeguez AD | Study Chair | |
| Pitt J | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Univ of Alabama at Birmingham Schl of Med / Pediatrics | Birmingham | Alabama | 35294 | United States | ||
| UCSD Med Ctr / Pediatrics / Clinical Sciences |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 8734001 | Background | Bardeguez AD. Management of HIV infection for the childbearing age woman. Clin Obstet Gynecol. 1996 Jun;39(2):344-60. doi: 10.1097/00003081-199606000-00009. No abstract available. | |
| Background | Bardeguez AD, Taylor U, Appuzio J, Leus C, Lister M, Denny T, Palumbo P, Connor E. Characteristics of pregnant women infected with human immunodeficiency virus 1: Newark perinatal transmission study. Int Conf AIDS. 1991 Jun 16-21;7(2):193 (abstract no WB2044) | ||
| Background | Japour AJ, Welles S, McIntosh K, Colson A, Chung P, Lockman S, Davenny K, Fowler MG, Hansen IC, Kalish L, Moye J, Rick K, Zorilla C, Pitt J. ZDV resistance (ZDVR) mutations in ZDV exposed mother infant pairs: preliminary findings from the women and infants transmission study (WITS). Int Conf AIDS. 1996 Jul 7-12;11(1):370 (abstract no TuC2606) | ||
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| La Jolla |
| California |
| 920930672 |
| United States |
| Long Beach Memorial (Pediatric) | Long Beach | California | 90801 | United States |
| Los Angeles County - USC Med Ctr | Los Angeles | California | 90033 | United States |
| UCLA Med Ctr / Pediatric | Los Angeles | California | 900951752 | United States |
| Harbor - UCLA Med Ctr / UCLA School of Medicine | Los Angeles | California | 905022004 | United States |
| Univ of Connecticut / Farmington | Farmington | Connecticut | 06032 | United States |
| Connecticut Children's Med Ctr - Pediatric | Hartford | Connecticut | 06106 | United States |
| Children's Hosp of Washington DC | Washington D.C. | District of Columbia | 200102916 | United States |
| Howard Univ Hosp | Washington D.C. | District of Columbia | 20060 | United States |
| Univ of Miami (Pediatric) | Miami | Florida | 33161 | United States |
| Univ of Chicago Children's Hosp | Chicago | Illinois | 606371470 | United States |
| Tulane Univ / Charity Hosp of New Orleans | New Orleans | Louisiana | 701122699 | United States |
| Univ Hosp | New Orleans | Louisiana | 70112 | United States |
| Johns Hopkins Hosp - Pediatric | Baltimore | Maryland | 212874933 | United States |
| Children's Hosp of Boston | Boston | Massachusetts | 021155724 | United States |
| Brigham and Women's Hosp | Boston | Massachusetts | 02115 | United States |
| Baystate Med Ctr of Springfield | Springfield | Massachusetts | 01199 | United States |
| Univ of Medicine & Dentistry of New Jersey / Univ Hosp | Newark | New Jersey | 071032714 | United States |
| Bellevue Hosp / New York Univ Med Ctr | New York | New York | 10016 | United States |
| Mount Sinai Med Ctr / Pediatrics | New York | New York | 10029 | United States |
| Columbia Presbyterian Med Ctr | New York | New York | 10032 | United States |
| Incarnation Children's Ctr / Columbia Presbyterian Med Ctr | New York | New York | 10032 | United States |
| Univ of Rochester Medical Center | Rochester | New York | 14642 | United States |
| SUNY Health Sciences Ctr at Syracuse / Pediatrics | Syracuse | New York | 13210 | United States |
| Bronx Lebanon Hosp Ctr | The Bronx | New York | 10457 | United States |
| Duke Univ Med Ctr | Durham | North Carolina | 277103499 | United States |
| Columbus Children's Hosp | Columbus | Ohio | 432052696 | United States |
| San Juan City Hosp | San Juan | 009367344 | Puerto Rico |
| Background |
| Garcia PM, Kalish LA, Pitt J, Minkoff H, Quinn TC, Burchett SK, Kornegay J, Jackson B, Moye J, Hanson C, Zorrilla C, Lew JF. Maternal levels of plasma human immunodeficiency virus type 1 RNA and the risk of perinatal transmission. Women and Infants Transmission Study Group. N Engl J Med. 1999 Aug 5;341(6):394-402. doi: 10.1056/NEJM199908053410602. |
| ID | Term |
|---|---|
| D015658 | HIV Infections |
| D011251 | Pregnancy Complications, Infectious |
| D000163 | Acquired Immunodeficiency Syndrome |
| D000386 | AIDS-Related Complex |
| ID | Term |
|---|---|
| D000086982 | Blood-Borne Infections |
| D003141 | Communicable Diseases |
| D007239 | Infections |
| D015229 | Sexually Transmitted Diseases, Viral |
| D012749 | Sexually Transmitted Diseases |
| D016180 | Lentivirus Infections |
| D012192 | Retroviridae Infections |
| D012327 | RNA Virus Infections |
| D014777 | Virus Diseases |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D007153 | Immunologic Deficiency Syndromes |
| D007154 | Immune System Diseases |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D012897 | Slow Virus Diseases |
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