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| ID | Type | Description | Link |
|---|---|---|---|
| Y01-3-0010-3 |
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The purpose of this study is to evaluate clinical safety issues pertaining to lisuride, to cocaine, and to its interaction in a chronic, crack dependent population, and to determine how pretreatment with lisuride modifies the subjective as well as physiological effects of cocaine.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Lisuride | Drug |
| Measure | Description | Time Frame |
|---|---|---|
| Degree of drug craving | ||
| History, incidence and amount of drug use | ||
| Type and severity of stimulant withdrawal symptoms | ||
| Characterization of study population | ||
| Population incidence of symptoms of depression, po | ||
| Frequency and intensity of drug use and sexual beh | ||
| Evidence of change in neurophysiology and brain ac | ||
| Evidence of change in subjective responses to coca | ||
| Clinical physiological response to cocaine challen | ||
| Degree to which study medication influences change |
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Inclusion Criteria:
M/F ages 21-50. Meet DSM-IV criteria for cocaine dependence. Agree to conditions of the study and sign informed consent.
Exclusion Criteria:
Psychiatric disorder that requires medication therapy. History of seizures. Pregnant and/or nuring women. Dependence on ETOH or benzodiazepines or other sedative/hypnotics. Acute hepatitis. Other medical condtions that deem participation to be unsafe.
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| Name | Affiliation | Role |
|---|---|---|
| Walter Ling, M.D. | Friends Research Institute, Inc. | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Friends Research Institute | Los Angeles | California | 90025 | United States |
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| ID | Term |
|---|---|
| D019970 | Cocaine-Related Disorders |
| ID | Term |
|---|---|
| D019966 | Substance-Related Disorders |
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D008090 | Lisuride |
| ID | Term |
|---|---|
| D004873 | Ergolines |
| D004876 | Ergot Alkaloids |
| D000470 | Alkaloids |
| D006571 | Heterocyclic Compounds |
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| D006576 |
| Heterocyclic Compounds, 4 or More Rings |
| D000072471 | Heterocyclic Compounds, Fused-Ring |