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| ID | Type | Description | Link |
|---|---|---|---|
| RO 1AG15922-01 |
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This is a three-year study to determine if estrogens can prevent memory loss and Alzheimer's disease in women with a family history of Alzheimer's disease.
PREventing Postmenopausal memory loss and Alzheimer's with Replacement Estrogens (PREPARE) is a double-blind-placebo controlled trial to determine whether estrogen (or estrogen and progesterone) can delay the onset of memory loss or Alzheimer's Disease in elderly women with a family history of the disease.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Estrogen | Drug | |||
| Estrogen and Progesterone | Drug |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Mary Sano, PhD | Icahn School of Medicine at Mount Sinai | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Alabama | Birmingham | Alabama | 35294 | United States | ||
| University of California, Irvine |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 8709781 | Background | Tang MX, Jacobs D, Stern Y, Marder K, Schofield P, Gurland B, Andrews H, Mayeux R. Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease. Lancet. 1996 Aug 17;348(9025):429-32. doi: 10.1016/S0140-6736(96)03356-9. | |
| 9191758 | Background | Kawas C, Resnick S, Morrison A, Brookmeyer R, Corrada M, Zonderman A, Bacal C, Lingle DD, Metter E. A prospective study of estrogen replacement therapy and the risk of developing Alzheimer's disease: the Baltimore Longitudinal Study of Aging. Neurology. 1997 Jun;48(6):1517-21. doi: 10.1212/wnl.48.6.1517. |
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| Irvine |
| California |
| 29697-4540 |
| United States |
| New England Center for Headache | Stamford | Connecticut | 06902-1249 | United States |
| Howard University | Washington D.C. | District of Columbia | 20060 | United States |
| Lee Memorial Health System | Fort Myers | Florida | 33901 | United States |
| Mayo Clinic Jacksonville | Jacksonville | Florida | 32225 | United States |
| Wein Center | Miami Beach | Florida | 33140 | United States |
| West Florida Regional Medical Center | Pensacola | Florida | 32514 | United States |
| North Broward Medical Center | Pompano Beach | Florida | United States |
| Tallahassee Memorial Health Center | Tallahassee | Florida | 32308 | United States |
| St. Mary's Medical Center | West Palm Beach | Florida | 33407 | United States |
| Johns Hopkins Bayview Medical Center | Baltimore | Maryland | 21224 | United States |
| Neurology Group of Bergen County | Ridgewood | New Jersey | 07450 | United States |
| Columbia University | New York | New York | 10032 | United States |
| Cornell Medical Center, New York Presbyterian Medical Center | New York | New York | United States |
| New York United Hospital Medical Center | Port Chester | New York | 10573 | United States |
| Burke Medical Research Institute | White Plains | New York | 10605 | United States |
| Duke University Medical Center | Durham | North Carolina | 27710 | United States |
| Clinical Pharmaceutical Trials | Tulsa | Oklahoma | 74104-5428 | United States |
| Butler Hospital, Rhode Island Hospital | Providence | Rhode Island | 02906 | United States |
| Medical University of South Carolina | North Charleston | South Carolina | 29406 | United States |
| Eastern Virginia Medical School | Norfolk | Virginia | 23507-1912 | United States |
| 9484355 | Background | Jacobs DM, Tang MX, Stern Y, Sano M, Marder K, Bell KL, Schofield P, Dooneief G, Gurland B, Mayeux R. Cognitive function in nondemented older women who took estrogen after menopause. Neurology. 1998 Feb;50(2):368-73. doi: 10.1212/wnl.50.2.368. |
| 17195882 | Result | Aloysi A, Van Dyk K, Sano M. Women's cognitive and affective health and neuropsychiatry. Mt Sinai J Med. 2006 Nov;73(7):967-75. |
| ID | Term |
|---|---|
| D000544 | Alzheimer Disease |
| D008569 | Memory Disorders |
| ID | Term |
|---|---|
| D003704 | Dementia |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D024801 | Tauopathies |
| D019636 | Neurodegenerative Diseases |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D004967 | Estrogens |
| D011374 | Progesterone |
| ID | Term |
|---|---|
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
| D045505 | Physiological Effects of Drugs |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |
| D011282 | Pregnenediones |
| D011283 | Pregnenes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D003339 | Corpus Luteum Hormones |
| D042341 | Gonadal Hormones |
| D045167 | Progesterone Congeners |
| D012739 | Gonadal Steroid Hormones |
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